As with most inbred animals there are always more genetic health problems. The gene that makes them white is linked to eye problems. White tigers always have poor vision, making them more dependent on their handler. In some cases this is easy to see as they may be cross eyed, in other cases the problem is in regards to how their eyes are wired to their brain. Some tiger trainers prefer white tigers because their poor vision makes them easier to train, they are more dependent on their handler than a tiger with normal health vision.
White tigers are often born with spinal deformities, cleft pallets (a mouth deformity), and organ problems. It is not uncommon for them to die shortly after birth.